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KMID : 0361420120360030340
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Journal of Korean Academy of Rehabilitation Medicine
2012 Volume.36 No. 3 p.340 ~ p.346
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Effect of Botulinum Toxin A Injection into the Salivary Glands for Sialorrhea in Children with Neurologic Disorders
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Jeung In-Seuk
Lee So-Young
Kim Heung-Sik
Yeo Chang-Ki
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Abstract
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Objective: To determine the 9 month period effect of botulinum toxin A (BoNT-A) injection into the salivary gland in children with neurologic disorders and sialorrhea by qualifi ed parent/caregiver-administered questionnaires.
Methods: A total of 17 patients (age 7.6±4.24 years) were enrolled in this study. The degree of sialorrhea was assessed at the baseline, 2 weeks, 1, 2, 4, 6 and 9 months after injection. The Drooling Count (DC) was assessed as an objective measurement. The Drooling Frequency and Severity Scale (DFS) and the Teacher Drooling Scale (TDS) were evaluated as a subjective measurement. BoNT-A (0.5 unit/kg) was injected into each submandibular and parotid gland under ultrasonography-guidance.
Results: DC, DFS and TDS showed significant improvement at 2 weeks, 1, 2, 4, 6, and 9 months follow-up (p<0.05). Twelve of 17 cases (70.5%) showed more than 50% reduction in DC from the baseline value.
Conclusion: Ultrasonography-guided BoNT-A injection into the submandibular and parotid gland was a safe and eff ective method to treat sialorrhea in children with neurologic disorders.
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KEYWORD
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Sialorrhea, Botulinum toxin, Salivary gland, Children, Neurologic disorder
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